Name Ying-Hen Hsieh Ying-Hen Hsieh
Title Professor
  • Department of Public Health, China Medical University
  • Address: 91 Hsueh-Shih Road, Taichung City 40402, Taiwan, R.O.C.
  • Tel: (886-4) 22053366 ext 6109
  • E-mail: hshieh@mail.cmu.edu.tw 
Resume Degree
  • Carnegie-Mellon University, M.S., Mathematics, 1976-1978.
  • Carnegie-Mellon University, Ph.D., Applied Mathematics, 1978-1982.
Professional experience
  • Associate Professor, Department of Applied Mathematics, National Chung Hsing University, 1982-87.
  • Professor, Department of Applied Mathematics, National Chung Hsing University, 1987-2007.
  • Chairman and Professor, Department of Applied Mathematics, National Chung Hsing University, 1995-97.
  • Professor, Department of Public Health, China Medical University, 2007-present.
  • Co-Executive Editor, Journal of Biological Systems, 2012-present.
Fields of Specialty
  • Mathematical Biology
  • Population Dynamics
  • Ordinary Differential Equations
  • Mathematical Ecology
  • Modeling and Analysis of Infectious Diseases and Public Health
  • Mathematical Modeling of Infectious Diseases Epidemiology
  1. Coleman, B.D. and Hsieh, Y.-H., (1979) Theory of the dependence of population levels on environmental history for semelparous species with short reproductive seasons. Proc. Natl. Acad. Sci. USA, 76(10):5407-5410. (SCI)
  2. Coleman, B.D., Hsieh, Y.-H. and Knowles, G.P., (1979) On the optimal choice of r for a population in a periodical environment. Math. Biosci. 45:159-173. (SCI)
  3. Coleman, B.D., Mares, M.A., Willig, M.R. and Hsieh, Y.-H,. 1982. Randomness, Area, and species richness. Ecology, 63(4):1121-1133. (SCI)
  4. Hsieh, Y.-H. 1985. On the use of optimal estimate in demography. J. Sci. Eng. NCHU, 22:211-226.
  5. Hsieh, Y.-H. 1986. A periodical population model. Proc. Natl. Sci. Council, ROC,    10(3):266-274.
  6. Hsieh, Y.-H. 1986. On density-dependent models and periodical populations, J. Sci. Eng. NCHU, 23:123-132.
  7. Coleman, B.D. and Hsieh, Y.-H.* 1986. On species-area relations: I. Random placement and sampling average, Soochow J. Math. 12:11-22.
  8. Coleman, B.D. and Hsieh, Y.-H.* 1987. On species-area relations: II. Estimates of abundance data. Soochow J. Math., 13(1):31-44.
  9. Hsieh, Y.-H. 1988. The phenomenon of unstable oscillation in population models. Math. Comput. Modeling, 10(6): 429-435. (SCI)
  10. Hsieh, Y.-H. 1989. On the evolution of altruism in an age-structured population. Math. Comput. Modeling, 11: 427-475. (SCI)
  11. Hsieh, Y.-H. 1990. An AIDS model with screening. Math. Comp. Mod., 14:640-643. (SCI)
  12. Hsieh, Y.-H. 1990. Evolution of altruism communities. COENOSES, 4(3): 145-147.
  13. Hsieh, Y.-H. 1991. Persistence of altruistic community under indiscriminate altruism. Proc. NSC(ROC), 15(1): 33-39.
  14. Hsieh, Y.-H. 1991. Modelling the effect of screening in HIV transmission dynamics. Differential Equations Models in Biology, Epiemiology and Ecology, Proc. Inter. Conf. on Diff. Eq. Claremont, Lec. Notes in Biomath., pp. 99-120. Springer-Verlag, New York.
  15. Hsieh, Y.-H. 1991. An altruistic population model with sex differences. Mathematical Population Dynamcis, Proc. 2nd Inter. Conf. Math. Popula. Dynamics. (O. Arino, D. Axelrod and M. Kimmel, eds.) Lecture Notes in Pure and Applied Mathematics, pp. 63-73. Marcel Dekker, Inc. New York.
  16. Hsieh, Y.-H. 1992. Optimal estimate of population structure under varying vital rates. Math. Popu. Studies, 3(4): 289-299.
  17. Velaso-Hernanadez, J.X. and Hsieh, Y.-H. 1994. Modeling the effect of treatment and behavioral change in HIV transmission dynamics. J. Math. Biol., 32:233-429. (SCI: Misc. Mathematics, Misc. Biology)
  18. Hsieh, Y.-H. and Velaso-Hernanadez, J. 1995. Community treatment of HIV-1: Initial and asymptotic dynamics. BioSystems, 35(1):75-81. (SCI: Biology)
  19. Busenberg, S., Cooke, K., and Hsieh, Y.-H. 1995. A model for HIV in Asia. Math. Biosci., 128(12):185-210. (SCI: Misc. Mathematics, Misc. Biology)
  20. Hsieh, Y.-H. 1996. A two-sex model for treatment of HIV and behavior change in a population of varying size. IMA J. Math. Appl. Med. Biol., 13:151-173. (SCI: Misc. Mathematics, Misc. Biology)  
  21. Chen, C.W.S., Lee, S.-M., Hsieh, Y.-H., and Ungchusak, K. (1999). A unified approach to estimating population size for births only models, Compu. Stat. Data Analysis, 32:29-46. (SCI: Statistics)
  22. Hsieh, Y.-H.* and Cooke, K. (2000) Behavior Change and Treatment of Core Group and Bridge Population: Its Effect on the Spread of HIV/AIDS. IMA J. of Math. Appl. Biol. Med. 17(3): 213-241.  (SCI: Mics. Mathematics, Misc. Biology)
  23. Hsieh, Y.-H.*, Chen, C.W.S., and Lee, S-M. (2000) Empirical Bayes approach to estimating the number of HIV-infected individuals in hidden and elusive populations. Stat. Med. 19: 3095-3108.  (SCI: Statistics, Public Health)
  24. Hsieh, Y.-H.*, Lee, S.-M., Chen, C.W.S., and Arazoza, H. (2001) On the recent sharp increase of HIV infections in Cuba. AIDS. 13(3):425-428. (SCI: Public Health, Infectious Diseases)
  25. Hsieh, Y.-H.* and Hsu, S.-P. (2001) The effect of density-dependent treatment/behavior change on the transmission dynamics of HIV. J. of Math. Biol. 43, 69-80. (SCI)
  26. Hsieh, Y.-H.*, Arazoza, H., Lee, S.-M., and Chen, C.W.S. (2002) Estimating the number of HIV-infected Cubans by sexual contact. Int. J. of Epidemiology. 31, 679-683. (SCI: Public Health)
  27. Hsieh, Y.-H. (2002) The changing faces of commercial sex in Thailand: its implications for HIV transmission. JAIDS. 30(5):537-540. (SCI: Public Health)
  28. Hsieh, Y.-H. (2003) Politics hindering SARS work. Nature. 423:381, May 22, 2003. (SCI Multidisciplinary Sciences)
  29. Hsieh, Y,-H.* and Chen, C.W.S. (2003) Severe Acute Respiratory Syndrome: Numbers do not tell whole story. British Med. Journal, 326:1395-1396, June 21, 2003. (SCI Medicine, General and Internal)
  30. Hsieh, Y.-H. (2003) SARS and the Internet. New Eng. J Medicine, 349(7): 711-2,August 14, 2003 (SCI Medicine, General and Internal)
  31. Hsieh Ying-Hen*, Cathy W.S. Chen. (2003) Re: Mathematical modeling of SARS: Cautious in all our movements. J Epidem Com Health, 2003; (18 November 2003). Available at http://jech.bmjjournals.com/cgi/eletters/57/6/DC1#66. (SCI Public Health)
  32. Li, C.-S., Liang, H. Hsieh, Y.-H., and Twu, S-J. (2003) Comparison of viral trajectories in AIDS Studies using nonparametric mixed-effects models.  Journal of Modern Applied Statistical Methods. 2003, 2(2):443-450.
  33. Hsieh, Y.-H.* and Chen, C.H. (2004) Modeling the social dynamics of the sex industry in Thailand:  Its implications for spread of HIV. Bull. Math. Biol. 66(1):143-166. (SCI Impact factor: 1.724, Mathematics, Interdisciplinary applications 24/70).
  34. Hsieh, Y.-H.* C.W-S. Chen and S.-B. Hsu. (2004) SARS outbreak, Taiwan 2003. Emerging Infectious Diseases. 10(2):201-206. Available online at: http://www.cdc.gov/ncidod/eid/vol10no2/03-0515.htm. (SCI Impact factor: 5.775, Infectious Diseases; 5/50)
  35. Hsieh, Y.-H.* J-Y Lee and H.L. Chang. (2004) SARS epidemiology modeling. Emerging Infectious Diseases; 10(6):1165-7, June 2004 (SCI Impact factor: 5.775, Infectious Diseases; 5/50).
  36. Hsieh Y,-H.*, Chen CWS, Hsu SB. SARS outbreak in Taiwan (reply to Hsueh and Yang). (2004) Emerging Infectious diseases, 10(8):1515-6, August 2004(SCI Impact factor: 5.775, Infectious Diseases; 5/50).
  37. Hsieh, Y.-H.*, Chen, CWS. (2004) Mathematical modeling of SARS: Errata and updates. J Epidem Com Health, published online May 11, 2004. Available at: http://jech.bmjjournals.com/cgi/eletters/57/6/DC1 (SCI Impact factor: 2.956, Public, Environmental and occupational health; 19/100).
  38. Hsieh, Y.-H. If we ignore politics, will politics ignore science? Nature. 2004. 432:671(SCI Impact factor: 28.751, Multidisciplinary Sciences; 1/50).
  39. Hsieh, Y.-H.*, de Arazoza Rodríguez, Héctor, Rachid Lounes. (2005) A Class of Models for HIV Contact Tracing in Cuba: Implications for Intervention and Treatment. To appear in "Deterministic and Stochastic Models for AIDS Epidemics and HIV Infection with Interventions." (Ed. W.Y. Tan). Singapore: World Scientific.
  40. Hsieh Y.-H.*, King CC, Ho MS, Chen CWS, Lee JY, Liu FC, Wu YC, Wu JSJ. (2005) Quarantine for SARS, Taiwan. Emerging Infectious Diseases; 11(2):278-82. (SCI Impact factor: 5.775, Infectious Diseases; 5/50).
  41. Hsieh, Y.-H. (2005) Despite some flaws, online submission is the future. Nature 435:1160. (SCI Impact factor: 28.751, Multidisciplinary Sciences; 1/50)
  42. Hsieh Y.-H. (2005) Mapping the complexities of science and politics. Nature 438, 24 (3 November 2005) (SCI Impact factor: 28.751, Multidisciplinary Sciences; 1/50)
  43. Hsieh, Y.-H.*, H.-C. Wang, H. de Arazoza, R. Lounes, S-.J. Twu, and H.-S. Hsu. (2005) Ascertaining HIV underreporting in low HIV prevalence settings. J. Biol. Systems, 13(4):441-454. (SCI Impact Factor: 0.547, Mathematics, Interdisciplinary applications; 53/70).
  44. Hsieh Y.-H.* and Y. S. Cheng. (2006) Real-time forecast of multi-wave epidemic outbreaks. Emerging Infectious Diseases; 12(1):122-7. (SCI Impact factor: 5.775, Infectious Diseases; 5/50).
  45. Chen, C.W.S. and Hsieh, Y.-H. (2006) Bias may be unintentional but it's still there. Nature, 439:18 (SCI Impact factor: 28.751, Multidisciplinary Sciences; 1/50).
  46. S.B. Hsu and Hsieh Y.-H.* (2006) Modeling intervention measures and public response during SARS outbreak. SIAM J. Appl Math, 66(2): 627-647. (SCI Impact Factor: 1.026, Applied Mathematics; 42/165).
  47. Hsieh, Y.-H.* and Y.-S. Wang. (2006) Basic reproduction number for HIV model incorporating commercial sex and behavior change. Bull. Math. Biol. 68: 551–575. (SCI impact factor: 1.724, Mathematics, Interdisciplinary applications; 24/70)
  48. Hsieh, Y.-H.*, S.M. Lee, C.W.S. Chen, Y.M. Chen, S.I. Wu, S.F. Lai, and A.L. Chang. (2006) Estimating the HIV-infected population size in hard-to-count populations: the case of gay sauna patrons in Taipei. Physica A. 362(2): 495-503. (SCI Impact Factor: 1.43, Physics, Multidisciplinary; 25/69).
  49. P. Georgescu and Y.-H. Hsieh*.  (2006) Global Stability for a Virus Dynamics Model with Nonlinear Incidence of Infection and Removal. SIAM J. Applied Mathematics, 67(2): 337-353. (SCI Impact Factor: 1.026, Applied Mathematics; 42/165).
  50. Hsieh Y.-H.*, C.C. King, C.W.S. Chen, M.S. Ho, S.B. Hsu, and YC Wu. (2007) Impact of Quarantine on the 2003 SARS Outbreak: a retrospective modeling study. J. Theoretical Biology, 244: 729-736. (SCI impact factor: 2.323, Biology; 5/26)
  51. Y.-H. Hsieh, P. van den Driessche, and L. Wang. (2007) A multi-patch model for spatial spread of disease: Impact of Travel between patches, Bull. Math. Biology, 69(4): 1355-75. (SCI impact factor: 1.724, Mathematics, Interdisciplinary applications; 24/70)
  52. Paul S.F. Yip, Y.-H. Hsieh, Tina Y. Xu, K.F. Lam, C. C. King, and H. L. Chang. Assessment of Intervention Measures for the 2003 SARS Epidemic in Taiwan by Use of a Back-Projection Method. Infect Control Hosp Epidemiol 2007; 28(5): 525-530.  (SCI Impact Factor: 2.989, Public, Environmental, and Occupational Health: 17/100)
  53. P. Georgescu and Y.-H. Hsieh*. (2007) Global Dynamics of a Predator-prey Model with Stage Structure for Predator, SIAM J. Applied Mathematics, 67(5): 1379-1395. (SCI Impact Factor: 1.026, Applied Mathematics; 42/165).
  54. S.B. Hsu and Hsieh Y.-H.* (2008) On the Role of Asymptomatic Infection in Transmission Dynamics of Infectious Diseases. Bull. Math. Biology, 70: 134-155. (SCI impact factor: 1.724, Mathematics, Interdisciplinary applications; 24/70).
  55. R. Lounes, H. de Arazoza, Y. H. Hsieh and J. Joanes. (2008) Deterministic modeling on the size of the HIV/AIDS epidemic in Cuba. In Mathematical Methods in Survival Analysis, Reliability and Quality of Life. C. Huber, N. Limnios, M. Mesbah, M. Nikulin (Editors) ISTE and J. Wiley, London, Chap. 20, p. 317-330.
  56. Hsieh Y.-H.* and Chin-Kuei Hsiao. (2008) A Predator-prey Model with Disease Infection in Both Populations, Mathematical Medicine and Biology, 25: 247-266. (SCI impact factor: 1.324, Biology; 35/70).
  57. Hsieh Y.-H. (2008) Richards Model: A Simple Procedure for Real-time Prediction of outbreak Severity. To appear in Modeling and Dynamics of Infectious Diseases. Zhien Ma Jianhong Wu, Yicang Zhou, eds. Series in Contemporary Applied Mathematics (CAM), Vol. 11, p. 218-239, Beijing, Higher Education Press.
  58. Hsieh Y.-H.* and Stefan Ma. Intervention Measures, Turning Point, and Reproduction Number for Dengue, Singapore, 2005. (2009) Am. J. Trop. Med. Hyg. 80(1):66-71. (SCI impact factor: 2.183, Tropical Medicine; 3/14)
  59. Y.-H. Hsieh* and C.W.S. Chen. Turning Points, reproduction number, and Impact of Climatological events on Multi-Wave Dengue Outbreaks. (2009) Trop. Med. International Health. 16(4):1-11. (SCI impact factor: 2.466, Tropical Medicine; 2/14).
  60. Y.-H. Hsieh* and Arazoza, H. (2009) Correspondence to “Universal voluntary HIV testing and immediate antiretroviral therapy”. Lancet; 373: 1079-1080. (SCI impact factor: 29.443, MEDICINE, GENERAL & INTERNAL; 2/132).
  61. Y.-H. Hsieh. Excess Deaths and immunoprotection during 1918–1920 Pandemic, Taiwan. Emerg. Infectious Dis. 2009; 15 (10): 1617-9. (SCI Impact factor: 6.497, Infectious Diseases; 3/57).
  62. Y.-H. Hsieh*, C.W.S. Chen, S.-F. Hsu-Schmitz, C.C. King, W.J. Chen, H.-L. Chang, and M.S. Ho. (2010) Candidate genes associated with susceptibility to SARS-CoV: A Modeling Study. Bull. Math. Biol. 72(1): 122-132.
  63. G. Webb, Y.-H. Hsieh, J. Wu, and M. Blaser. (2010) Pre-symptomatic Influenza Transmission, Surveillance, and School Closings. Math. Model. Natural Phenomena, 5(3): 191-205.
  64. Y.-H. Hsieh. (2010) Age Groups and Spread of Influenza: Implications for Vaccination Strategy. BMC Inf. Diseases; 10:106. (SCI impact factor: 2.550, Infectious Diseases; 27/57)
  65. C. Sun and Y.-H. Hsieh. Global analysis of an SEIR model with varying population size and vaccination. Applied Math. Modeling, 34 (2010) 2685–2697. (SCI impact factor: 1.375, ENGINEERING, MULTIDISCIPLINARY; 17/79).
  66. P. Georgescu, Y.-H. Hsieh*, H. Zhang. 2010. A Lyapunov functional for a stage-structured predator-prey model with nonlinear predation rate. Nonlinear Anal: B. Real World Appl. 11(5): 3653-3665. (SCI impact factor: 2.381, Mathematics, Applied; 5/202)
  67. Y.-H. Hsieh, Yun-Shih Wang, Hector de Arazoza, and R. Lounes. 2010. HIV Model with Secondary Contact Tracing: Impact of Partner Notification Program in Cuba. BMC Inf. Diseases. 10:194  (SCI impact factor: 2.550, Infectious Diseases; 27/57)
  68. Y.-H. Hsieh. Pandemic Influenza A (H1N1) during Winter Influenza Season in the Southern Hemisphere. 2010. Influenza and other Respiratory Viruses, 4(4): 187-197.
  69. Y.-H. Hsieh*, D. Fisman, and J. Wu. 2010. Epidemic Modeling in Real Time: 2009 Novel A (H1N1) Influenza Outbreak in Canada. BMC Research Notes 2010, 3:283.
  70. D.Y. Chao, K.F. Cheng, Y.-H. Hsieh, T.C. Li, T.N. Wu, C.Y. Chen, C.A. Tsai, J.H. Chen, J.J. Lu, M.C. Su, Y.H. Liao, W.C. Chan. 2010. Serological Response and Persistence in Schoolchildren with High Baseline Seropositive Rate after Receiving 2009 Pandemic Influenza A(H1N1) Vaccine. Vaccine, 29(4): 617-623. (SCI impact factor: 3.616, MEDICINE, RESEARCH & EXPERIMENTAL; 20/93)
  71. Y.-H. Hsieh* and C.H. Chan. 2011. Excess Healthcare Burden during 1918-1920 Influenza Pandemic in Taiwan: Implications for Post-pandemic Preparedness. BMC Public Health, 11:41. (SCI impact factor: 2.223, Public, Environmental, and Occupational Health; 44/122)
  72. D.Y. Chao, K.F. Cheng, T.C. Li, T.N. Wu, C.Y. Chen, C.A. Tsai, J.H. Chen, J.J. Lu, M.C. Su, Y.H. Liao, W.C. Chan, Y.-H. Hsieh*. 2011. Serological Evidence of Subclinical Transmission of the 2009 Pandemic H1N1 Influenza Virus Outside of Mexico. PLoS ONE, 6(1): e14555. (SCI impact factor: 4.351, Biology; 10/76)
  73. R. Lounes, H. de Arazoza, A. Sanchez, J. Barrios and Y-H Hsieh. (2011) Modeling Detection of HIV in Cuba. Advances in Computational Intelligence, Springer Lecture Notes in Computer Science (LNCS) 6692 (Joan Cabestany, Ignacio Rojas and Gonzalo Joya, editors), Springer: 524-531.
  74. Das P, Mukherjee D, Hsieh YH. 2011. An S-I Epidemic Model with Saturation Incidence: Discrete and Stochastic Version. International Journal of Nonlinear Analysis and Applications, (1) 1-9.
  75. Y.-H. Hsieh*, S. Ma, J. Valasco-Hernandez, V. Lee, L. W. Yen. (2011) Early Outbreak of 2009 Influenza A (H1N1) in Mexico Prior to Identification of pH1N1 Virus. PLoS ONE, 6 (8): e23853. (SCI impact factor: 4.411, Biology; 12/85)
  76. D.Y. Chao, K.F. Cheng, T.C. Li, T.N. Wu, C.Y. Chen, C.A. Tsai, J.H. Chen, J.J. Lu, M.C. Su, Y.H. Liao, W.C. Chan, Y.-H. Hsieh*. (2011) Factors Associated with Infection by 2009 Pandemic H1N1 Influenza Virus during Different Phases of Epidemic. Int. J. of Infectious Diseases. 15 (2011) e695–e701. (SCI impact factor: 2.529, Infectious Diseases; 31/58)
  77. Y.-H. Hsieh*, K.F. Cheng, D.Y. Chao, T.N. Wu, T.C. Li, C.Y. Chen, C.A. Tsai, J.H. Chen, M.H. Lin. Transmissibility and Temporal Changes of 2009 pH1N1 Pandemic during Summer and Fall/Winter Waves. BMC Inf. Diseases (2011) 11:332. (SCI impact factor: 2.825, Infectious Diseases; 27/58)
  78. Y.-H. Hsieh* and Mei-Hui Lin. 1919 Influenza Pandemic in Australia: Temporal and Spatial Spreads. Canadian Applied Mathematics Quarterly, (2011) 19(2): 171-184.
  79. Ying-Hen Hsieh*, Yuhua Ruan, Cathy W. S. Chen, Wei Shi, Dongliang Li, Fengji Luo, and Yiming Shao. HIV prevalence and underreporting of men who have sex with men in Beijing. Int J STD AIDS. (2012) 23:606—607. (SCI impact factor: Infectious Diseases; 1.082, 51/58)
  80. Ying-Hen Hsieh*. Ascertaining the 2004-2006 HIV Type 1 CRF07_BC Outbreak among Injecting Drug Users in Taiwan, International J. Infectious Diseases, 17 (2013) e838–e844. (SCI impact factor: 2.529, Infectious Diseases; 31/58)
  81. Y-H Hsieh*, H. de Arazoza, and R. Lounes. Temporal Trends and Regional Variability of 2001-2002 Multi-wave DENV-3 Epidemic in Havana City: Did Hurricane Michelle Contribute to its Severity? Tropical Medicine & International Health. 18(7): 830–838 (2013) (SCI impact factor: 2.841, Tropical Medicine; 3/19)
  82. Y.-H. Hsieh*, Chen-An Tsai, Jin-Hwa Chen, Chien-Yu Lin, Chwan-Chuen King, Day-Yu Chao, Kuang-Fu Cheng. Asymptomatic Ratio for Influenza Infection among Schoolchildren in Taiwan: Results from a Sero-epidemiological Study. BMC Infectious Diseases (2014) 14:80.
  83. Y.-H. Hsieh*, Junli Liu, Y.-H. Tzeng, Jianhong Wu, Impact of visitors and hospital staff on nosocomial transmission and spread to community, Journal of Theoretical Biology, 356(2014): 20–29.
  84. Day-Yu Chao, Kuang-Fu Cheng, Ying-Hen Hsieh, Tsai-Chung Li, Trong-Neng Wu, Chiu-Ying Chen. Geographical Heterogeneity and Influenza Infection Within Households. BMC Infectious Diseases (2014), 14:369.
  85. YH Hsieh*, J Fang, J Lou, Y Yang, J Wu. Quantification of Bird-to-Bird and Bird-to-Human Infections during 2013 Novel H7N9 Avian Influenza Outbreak in China. PLoS ONE (2014), DOI:10.1371/journal.pone.0111834. 
  86. Chao, D., Cheng, K., Liao, Y., Liu, M., Hsieh, Y., Li, T., Wu, T., and Chen, C. (2014) Immunological Responses against Different Lineages of Influenza B Antigen in School Children during Two Consecutive Seasons. Health, 6, 2837-2847.